[HTML][HTML] Respiratory epithelial cells orchestrate pulmonary innate immunity

JA Whitsett, T Alenghat - Nature immunology, 2015 - nature.com
The epithelial surfaces of the lungs are in direct contact with the environment and are
subjected to dynamic physical forces as airway tubes and alveoli are stretched and …

Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions

WJ Janssen, AL Stefanski, BS Bochner… - European Respiratory …, 2016 - Eur Respiratory Soc
Owing to the need to balance the requirement for efficient respiration in the face of
tremendous levels of exposure to endogenous and environmental challenges, it is crucial for …

CFAP54 is required for proper ciliary motility and assembly of the central pair apparatus in mice

CW McKenzie, B Craige, TV Kroeger… - Molecular biology of …, 2015 - Am Soc Cell Biol
Motile cilia and flagella play critical roles in fluid clearance and cell motility, and dysfunction
commonly results in the pediatric syndrome primary ciliary dyskinesia (PCD). CFAP221, also …

Chemoattractants and cytokines in primary ciliary dyskinesia and cystic fibrosis: key players in chronic respiratory diseases

M Cockx, M Gouwy, J Van Damme… - Cellular & molecular …, 2018 - nature.com
Patients with primary ciliary dyskinesia (PCD) and cystic fibrosis (CF), two inherited
disorders, suffer from recurrent airway infections characterized by persistent bacterial …

Analysis of genetic host response risk factors in severe COVID-19 patients

K Taylor, S Das, M Pearson, J Kozubek, M Pawlowski… - medRxiv, 2020 - medrxiv.org
ABSTRACT BACKGROUND Epidemiological studies indicate that as many as 20% of
individuals who test positive for COVID-19 develop severe symptoms that can require …

Strong selection signatures for Aleutian disease tolerance acting on novel candidate genes linked to immune and cellular responses in American mink (Neogale vison …

SM Vahedi, S Salek Ardestani, MH Banabazi… - Scientific Reports, 2024 - nature.com
Aleutian disease (AD) is a multi-systemic infectious disease in American mink (Neogale
vison) caused by Aleutian mink disease virus (AMDV). This study aimed to identify candidate …

Genetic interaction between central pair apparatus genes CFAP221, CFAP54, and SPEF2 in mouse models of primary ciliary dyskinesia

CW McKenzie, L Lee - Scientific Reports, 2020 - nature.com
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous syndrome that results from
defects in motile cilia. The ciliary axoneme has a 9+ 2 microtubule structure consisting of …

Strain-specific differences in brain gene expression in a hydrocephalic mouse model with motile cilia dysfunction

CW McKenzie, CC Preston, R Finn, KM Eyster… - Scientific Reports, 2018 - nature.com
Congenital hydrocephalus results from cerebrospinal fluid accumulation in the ventricles of
the brain and causes severe neurological damage, but the underlying causes are not well …

Strain-dependent brain defects in mouse models of primary ciliary dyskinesia with mutations in Pcdp1 and Spef2

R Finn, CC Evans, L Lee - Neuroscience, 2014 - Elsevier
Hydrocephalus is caused by the accumulation of cerebrospinal fluid (CSF) in the cerebral
ventricular system which results in an enlargement of the cranium due to increased …

Effect of Shin'iseihaito (Xinyiqingfeitang) on Acute Streptococcus pneumoniae Murine Sinusitis via Macrophage Activation

M Minami, T Konishi, H Takase, Z Jiang… - Evidence‐Based …, 2017 - Wiley Online Library
Streptococcus pneumoniae (S. pneumoniae) causes sinusitis. The general treatment of S.
pneumonia sinusitis is by using antibiotics; however, one of their serious problems is the …