[HTML][HTML] A comprehensive review of rosmarinic acid: From phytochemistry to pharmacology and its new insight

H Guan, W Luo, B Bao, Y Cao, F Cheng, S Yu, Q Fan… - Molecules, 2022 - mdpi.com
Polyphenolic acids are the widely occurring natural products in almost each herbal plant,
among which rosmarinic acid (RA, C18H16O8) is well-known, and is present in over 160 …

[HTML][HTML] Therapeutic potential of rosmarinic acid: A comprehensive review

M Nadeem, M Imran, T Aslam Gondal, A Imran… - Applied Sciences, 2019 - mdpi.com
Naturally occurring food-derived active ingredients have received huge attention for their
chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) …

[HTML][HTML] Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications

S Ijaz, J Iqbal, BA Abbasi, Z Ullah, T Yaseen… - Biomedicine & …, 2023 - Elsevier
Cancer is still the leading cause of death worldwide, burdening the global medical system.
Rosmarinic acid (RA) is among the first secondary metabolites discovered and it is a …

[HTML][HTML] Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

J Moore, M Yousef, E Tsiani - Nutrients, 2016 - mdpi.com
Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of
cancer cells to evade homeostasis and proliferate uncontrollably while avoiding …

Inhibitory effects of triterpenoid betulin on inflammatory mediators inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin-6, and …

J Yu, M Li, D Zhan, C Shi, L Fang, C Ban… - Pharmacognosy …, 2020 - phcog.com
Background: Colon carcinogenesis is the third most commonly occurring malignant
neoplasm and the second most common cause of cancer-related deaths globally. Betulin …

Rosmarinic acid: modes of action, medicinal values and health benefits

M Alagawany, ME Abd El-Hack, MR Farag… - Animal Health …, 2017 - cambridge.org
The supplementation of livestock rations with herbs containing bioactive components, such
as rosmarinic acid (RA), have shown promising results as a natural feed additive in …

[HTML][HTML] Rosmarinic acid–pharmaceutical and clinical aspects

SKS Amoah, LP Sandjo, JM Kratz, MW Biavatti - Planta medica, 2016 - thieme-connect.com
The biosynthesis and biotechnological production of Rosmarinic acid, a phenolic ester that
is widespread in the plant kingdom, has been widely investigated. This compound has …

Dietary phytochemicals in colorectal cancer prevention and treatment: A focus on the molecular mechanisms involved

S Afrin, F Giampieri, M Gasparrini… - Biotechnology …, 2020 - Elsevier
Worldwide, colorectal cancer (CRC) remains a major cancer type and leading cause of
death. Unfortunately, current medical treatments are not sufficient due to lack of effective …

Balancing the non-linear rosmarinic acid biosynthetic pathway by modular co-culture engineering

Z Li, X Wang, H Zhang - Metabolic engineering, 2019 - Elsevier
Pathway balancing is a critical and common challenge for microbial biosynthesis using
metabolic engineering approaches. Non-linear biosynthetic pathways, such as diverging …

Polyphenols in colorectal cancer: current state of knowledge including clinical trials and molecular mechanism of action

MN Alam, M Almoyad, F Huq - BioMed research international, 2018 - Wiley Online Library
Polyphenols have been reported to have wide spectrum of biological activities including
major impact on initiation, promotion, and progression of cancer by modulating different …