Epithelial ovarian cancer generally presents at an advanced stage and is the most common
cause of gynaecological cancer death. Treatment requires expert multidisciplinary care …

The inherent molecular heterogeneity of metastatic tumors and the ability of cancer
genomes to dynamically evolve are not properly captured by tissue specimens. Analysis of …

Brain microglia (MG) may serve as a human immunodeficiency virus 1 (HIV) reservoir and
ignite rebound viremia following cessation of antiretroviral therapy (ART), but they have yet …

High-grade serous ovarian cancer (HGSC) is frequently characterized by homologous
recombination (HR) DNA repair deficiency and, while most such tumors are sensitive to …

Characterizing and monitoring tumor genomes with blood samples could achieve significant
improvements in precision medicine. As tumors shed parts of themselves into the circulation …

Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish
a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and …

The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including the
lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC) …

Although melanoma is initiated by acquisition of point mutations and limited focal copy
number alterations in melanocytes-of-origin, the nature of genetic changes that characterise …

Chimeric antigen receptor (CAR) T cells have transformed the treatment landscape for
hematological malignancies. However, CAR T cells are less efficient against solid tumors …

Background Understanding the cancer genome is seen as a key step in improving outcomes
for cancer patients. Genomic assays are emerging as a possible avenue to personalised …