SUMMARY 1 After an outline description of pancreatic structure and function, and a more
detailed account of acinar cell morphology, this review traces the pathway of amino acids as …

The first encounter was inauspicious. But the serendipity of the artifact did not escape
Ringer's attention. He wrote (Ringer 1883):" After the publication of a paper in the Journal of …

Calcium is one of the most pleiotropic second messengers in all living organisms. However,
signalling specificity is encoded via spatio-temporally regulated signatures that act with …

1. Secretagogues of pancreatic enzyme secretion: pancreozymin, carbamylcholine, gastrin I,
the octapeptide of pancreozymin, caerulein and the Ca2+ ionophore A 23187 stimulate …

1. Fluxes of 45Ca2+ were studied in pancreatic islets from non‐inbred ob/ob‐mice. Because
La3+ blocked the transmembrane fluxes of 45Ca2+ in islet cells, incubations aimed at …

The term stimulus-secretion coupling refers to all those events occurring in the cell on
exposure to an appropriate stimulus that lead to discharge of secretory product. In cells …

1. Fluxes and distribution of Ca were studied in the perfused rat liver. Kinetic analysis of
45Ca exchange revealed three compartments with time constants of 4, 14 and 223 min, pool …

Subcellular distribution of the divalent cation-sensitive probe chlorotetracycline (CTC) was
observed by fluorescence microscopy in isolated pancreatic acinar cells, dissociated …

1. Intracellular recordings of membrane potential, input resistance and time constant have
been made in vitro from the exocrine acinar cells of the mouse pancreas using glass micro …

Bombesin caused depolarization of rat or mouse pancreatic acinar cell membrane,
reduction of membrane resistance, and a steep rise in amylase output from superfused …