Simple Summary Through their regulatory effects on gene expression, histone
acetyltransferases have been implicated in the normal physiological activities and genesis …

The bromodomain acts to recognize acetylated lysine in histones and transcription proteins
and plays a fundamental role in chromatin-based cellular processes including gene …

In recent years, substantial research has been conducted on molecular mechanisms and
inhibitors targeting bromodomains (BRDs) and extra-terminal (BET) family proteins. On this …

CREB (cyclic-AMP responsive element binding protein) binding protein (CBP) is a potential
target for prostate cancer treatment. Herein, we report the structural optimization of a series …

Due to the contribution of highly homologous acetyltransferases CBP and p300 to
transcription elevation of oncogenes and other cancer promoting factors, these enzymes …

Chemical discovery efforts commonly target individual protein domains. Many proteins,
including the EP300/CBP histone acetyltransferases (HATs), contain several targetable …

Bromodomain (BD) is an evolutionarily conserved protein module found in 46 different BD-
containing proteins (BCPs). BD acts as a specific reader for acetylated lysine residues (KAc) …

Post-translational modifications (PTMs) play a crucial role in regulating protein function, and
their dysregulation is frequently associated with various diseases. The emergence of …

The bromodomain of CREB (cyclic-AMP response element binding protein) binding protein
(CBP) is an epigenetic “reader” and plays a key role in transcriptional regulation. CBP …

A transition-metal-free postmodification of the Groebke–Blackburn–Bienaymé (GBB)
reaction for the synthesis of spiro [chromene-imidazo [1, 2-a] pyridin]-3′-imine was …