Inherited platelet disorders are important conditions that often manifest with bleeding. These
disorders have heterogeneous underlying pathologies. Some are syndromic disorders with …

Blood coagulation comprises a series of enzymatic reactions leading to thrombin generation
and fibrin formation. This process is commonly illustrated in a waterfall-like manner, referred …

Introduction Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of the extrinsic
pathway that negatively regulates thrombin production during coagulation. Under …

Abstract Background Factor (F) XI deficiency is associated with increased bleeding risk in
some individuals. Neither FXI levels nor clinical clotting assays predict the bleeding risk …

Background Underlying mechanisms for bleeding and impaired thrombin generation (TG)
and plasma clot formation (PCF) in patients with mild to moderate bleeding disorders …

Background The variability in bleeding patterns among individuals with hemophilia A, who
have similar factor VIII (FVIII) levels, is significant and the origins are unknown. Objective To …

Endothelial dysfunction, one of many causes of arterial changes in end-stage kidney
disease (kidney failure), is a likely link between early vascular aging and the risk of …

Anticoagulant therapy is a mainstay in the management of patients with cardiovascular
disease and related conditions characterized by a heightened risk for thrombosis. Acute …

Correct interpretation of the data from integral laboratory tests, including Thrombin
Generation Test (TGT), requires biochemistry-based mathematical models of blood …

Introduction Studies of thrombin generation (TG) with platelet‐rich plasma (PRP) and
platelet‐poor plasma (PPP) have provided insights on bleeding disorders. We studied TG for …