Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …

The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …

Fc receptors (FcRs) belong to the ITAM-associated receptor family. FcRs control the humoral
and innate immunity which are essential for appropriate responses to infections and …

Although recent evidence demonstrates heterogeneity among CD8+ T cells during chronic
infection, developmental relationships and mechanisms underlying their fate decisions …

Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …

T cells are critical in orchestrating protective immune responses to cancer and an array of
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …

This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …

Adoptive cell transfer using chimeric antigen receptors (CAR) has emerged as one of the
most promising new therapeutic modalities for patients with relapsed or refractory B-cell …