Consensus on diagnosis and management of Cushing's disease: a guideline update

M Fleseriu, R Auchus, I Bancos… - The lancet Diabetes & …, 2021 - thelancet.com
Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term
management to optimise patient outcomes. The Pituitary Society convened a consensus …

An individualized approach to the management of Cushing disease

M Fleseriu, EV Varlamov, JM Hinojosa-Amaya… - Nature Reviews …, 2023 - nature.com
Cushing disease caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary
corticotroph adenoma leads to hypercortisolaemia with high mortality due to metabolic …

Efficacy and safety of osilodrostat in patients with Cushing's disease (LINC 3): a multicentre phase III study with a double-blind, randomised withdrawal phase

R Pivonello, M Fleseriu, J Newell-Price… - The Lancet Diabetes & …, 2020 - thelancet.com
Background Cushing's disease is a rare endocrine disorder characterised by cortisol
overproduction with severe complications. Therapies for cortisol reduction are often …

Surgery and perioperative management of patients with Cushing's disease

J Honegger, I Nasi‐Kordhishti - Journal of Neuroendocrinology, 2022 - Wiley Online Library
Transsphenoidal surgery (TSS) is the initial treatment modality of first choice in Cushing's
disease (CD). With microscopic TSS and endoscopic TSS, two operative techniques with …

Hypercoagulability in Cushing syndrome, prevalence of thrombotic events: a large, single-center, retrospective study

MG Suarez, M Stack… - Journal of the …, 2020 - academic.oup.com
Abstract Background The risk of Cushing syndrome (CS) patients experiencing a thrombotic
event (TE) is significantly higher (odds ratio; OR 18%) than that of the general population …

Medical management of Cushing's disease: When and how?

F Castinetti - Journal of Neuroendocrinology, 2022 - Wiley Online Library
Transsphenoidal surgery is the first‐line treatment of Cushing's disease. However, medical
treatment can be given in a high proportion of patients with this rare condition. This is …

Management of endocrine disease: cardiovascular risk assessment, thromboembolism, and infection prevention in Cushing's syndrome: a practical approach

EV Varlamov, F Langlois, G Vila… - European journal of …, 2021 - academic.oup.com
Cushing's syndrome (CS) is associated with increased mortality that is driven by
cardiovascular, thromboembolic, and infection complications. Although these events are …

Acute and life-threatening complications in Cushing syndrome: prevalence, predictors, and mortality

MH Schernthaner-Reiter, C Siess… - The Journal of …, 2021 - academic.oup.com
Context Cushing syndrome (CS) results in significant morbidity and mortality. Objective To
study acute and life-threatening complications in patients with active CS. Methods We …

Diagnosis and management of hypertension in patients with Cushing's syndrome: a position statement and consensus of the Working Group on Endocrine …

F Fallo, G Di Dalmazi, F Beuschlein… - Journal of …, 2022 - journals.lww.com
Endogenous/exogenous Cushing's syndrome is characterized by a cluster of systemic
manifestations of hypercortisolism, which cause increased cardiovascular risk. Its biological …

Hypercortisolemia recurrence in Cushing's disease; a diagnostic challenge

JM Hinojosa-Amaya, EV Varlamov… - Frontiers in …, 2019 - frontiersin.org
Cushing's disease recurrence following successful pituitary surgery is common and merits
prompt and careful diagnosis, as untreated hypercortisolism leads to increased morbidity …