The main limitation to the success of central nervous system (CNS) therapies lies in the
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …

Nanomedicine is currently focused on the design and development of nanocarriers that
enhance drug delivery to the brain to address unmet clinical needs for treating …

The present work focuses on the development of surface modified transferrin PLGA
nanoparticles loaded with clonidine for nose to brain delivery. The CLD-Tf-PLGA-NPs were …

The present study aimed to prepare, characterize, and evaluate a thermo-responsive sol–
gel for intranasal delivery of lamotrigine (LTG), which was designed for sustained drug …

This advanced review describes the anatomical and physiological barriers and mechanisms
impacting nanomedicine translocation from the nasal cavity directly to the brain. There are …

We overviewed the anatomy and physiology of the nose-to-brain pathway, along with the
mechanisms involved. We then summarized the interaction process between nanoparticles …

Aim Present study focuses on the development of P80 coated PLGA Nanoparticles loaded
with drugs, paroxetine (P80-Par-PLGA-NPs) and clonidine (P80-CLD-PLGA-NPs) for in-vitro …

Current management of anesthesia‐associated complications falls short in terms of both
efficacy and safety. Nanomaterials with versatile properties and unique nano‐bio …

The well-known chemical drug oxcarbazepine (OXZ) is used to treat partial and secondary
generalized tonic-clonic seizures. Because extended-release formulations of antiepileptic …

Lamotrigine (LTG) is a second-generation antiepileptic drug that belongs to
Biopharmaceutics Classification System (BCS) class II. LTG has a low probability of crossing …