Metastasis
S Gerstberger, Q Jiang, K Ganesh - Cell, 2023 - cell.com
Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …
Cancer cell plasticity during tumor progression, metastasis and response to therapy
A Pérez-González, K Bévant, C Blanpain - Nature cancer, 2023 - nature.com
Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
J Liu, Q Xiao, J Xiao, C Niu, Y Li, X Zhang… - Signal transduction and …, 2022 - nature.com
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
Dynamic EMT: a multi‐tool for tumor progression
S Brabletz, H Schuhwerk, T Brabletz… - The EMBO journal, 2021 - embopress.org
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
Linking EMT programmes to normal and neoplastic epithelial stem cells
AW Lambert, RA Weinberg - Nature Reviews Cancer, 2021 - nature.com
Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …
and repair of diverse tissues through their ability to self-renew and spawn more specialized …
Colorectal liver metastasis: molecular mechanism and interventional therapy
H Zhou, Z Liu, Y Wang, X Wen, EH Amador… - Signal transduction and …, 2022 - nature.com
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …
Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies
ZD Shi, K Pang, ZX Wu, Y Dong, L Hao… - … and Targeted Therapy, 2023 - nature.com
Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …
Cancer stem cells—origins and biomarkers: perspectives for targeted personalized therapies
L Walcher, AK Kistenmacher, H Suo, R Kitte… - Frontiers in …, 2020 - frontiersin.org
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …
Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells
A Cañellas-Socias, C Cortina, X Hernando-Momblona… - Nature, 2022 - nature.com
Abstract Around 30–40% of patients with colorectal cancer (CRC) undergoing curative
resection of the primary tumour will develop metastases in the subsequent years. Therapies …
resection of the primary tumour will develop metastases in the subsequent years. Therapies …
Antibody targeting of E3 ubiquitin ligases for receptor degradation
Most current therapies that target plasma membrane receptors function by antagonizing
ligand binding or enzymatic activities. However, typical mammalian proteins comprise …
ligand binding or enzymatic activities. However, typical mammalian proteins comprise …