The immune functions of keratinocytes in skin wound healing
As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair
not only as structural cells but also exerting important immune functions. This review focuses …
not only as structural cells but also exerting important immune functions. This review focuses …
Cathelicidins modulate TLR-activation and inflammation
MR Scheenstra, RM Van Harten… - Frontiers in …, 2020 - frontiersin.org
Cathelicidins are short cationic peptides that are part of the innate immune system. At first,
these peptides were studied mostly for their direct antimicrobial killing capacity, but …
these peptides were studied mostly for their direct antimicrobial killing capacity, but …
Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes
Y Zhang, V Bharathi, T Dokoshi… - Proceedings of the …, 2024 - National Acad Sciences
It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
leads to the strong but ineffective inflammatory response that characterizes severe …
leads to the strong but ineffective inflammatory response that characterizes severe …
Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …
highly engage into research on alternative strategies to the traditional small molecule …
Immunomodulatory role of the antimicrobial LL-37 peptide in autoimmune diseases and viral infections
B Pahar, S Madonna, A Das, C Albanesi, G Girolomoni - Vaccines, 2020 - mdpi.com
Antimicrobial peptides (AMPs) are produced by neutrophils, monocytes, and macrophages,
as well as epithelial cells, and are an essential component of innate immunity system …
as well as epithelial cells, and are an essential component of innate immunity system …
Psoriasis and antimicrobial peptides
T Takahashi, K Yamasaki - International journal of molecular sciences, 2020 - mdpi.com
Psoriasis is a systemic inflammatory disease caused by crosstalk between various cells
such as T cells, neutrophils, dendritic cells, and keratinocytes. Antimicrobial peptides (AMPs) …
such as T cells, neutrophils, dendritic cells, and keratinocytes. Antimicrobial peptides (AMPs) …
CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis and
vasculopathy. CXCL4 represents an early serum biomarker of severe SSc and likely …
vasculopathy. CXCL4 represents an early serum biomarker of severe SSc and likely …
Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis
Y Nakamura, NN Kulkarni, T Takahashi… - The Journal of …, 2024 - Am Soc Clin Investig
Patients with chronic inflammatory disorders such as psoriasis have an increased risk of
cardiovascular disease and elevated levels of LL37, a cathelicidin host defense peptide that …
cardiovascular disease and elevated levels of LL37, a cathelicidin host defense peptide that …
Expanding structural space for immunomodulatory nucleic acid nanoparticles via spatial arrangement of their therapeutic moieties
Different therapeutic nucleic acids (TNAs) can be unified in a single structure by their
elongation with short oligonucleotides designed to self‐assemble into nucleic acid …
elongation with short oligonucleotides designed to self‐assemble into nucleic acid …
Type1 interferons potential initiating factors linking skin wounds with psoriasis pathogenesis
L Zhang - Frontiers in immunology, 2019 - frontiersin.org
Psoriasis is a chronic autoimmune skin disease that can often be triggered upon skin injury,
known as Koebner phenomenon. Type 1 interferons (IFNα and IFNβ), key cytokines that …
known as Koebner phenomenon. Type 1 interferons (IFNα and IFNβ), key cytokines that …