The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Type 2 diabetes mellitus (T2DM) is a very complex and multifactorial metabolic disease
characterized by insulin resistance and β cell failure leading to elevated blood glucose …

Improvements in health care and lifestyle have led to an elevated lifespan and increased
focus on age-associated diseases, such as neurodegeneration, cardiovascular disease …

The formation and accumulation of advanced glycation endproducts (AGEs) are related to
diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl …

Oxidative stress and oxidative damage to tissues are common end points of chronic
diseases, such as atherosclerosis, diabetes, and rheumatoid arthritis. The question …

Vlassara H, Palace MR (Department of Geriatrics, Division of Experimental Diabetes and
Ageing, Mount Sinai School of Medicine, and Department of Medicine, Division of …

Objective: This is the first part of a bipartite review that summarizes the rising knowledge on
the molecular mechanisms underlying the action of advanced glycation endproducts (AGEs) …

N (epsilon)-(Carboxymethyl) lysine (CML), a major product of oxidative modification of
glycated proteins, has been suggested to represent a general marker of oxidative stress and …

Recent studies suggested that interruption of the interaction of advanced glycation end
products (AGEs), with the signal-transducing receptor receptor for AGE (RAGE), by …

Although different theories have been proposed to explain the aging process, it is generally
agreed that there is a correlation between aging and the accumulation of oxidatively …