The JAK-STAT pathway at 30: Much learned, much more to do
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
The human genetic epidemiology of COVID-19
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia
Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical
COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in …
COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in …
Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank
Abstract The UK Biobank Exome Sequencing Consortium (UKB-ESC) is a private–public
partnership between the UK Biobank (UKB) and eight biopharmaceutical companies that …
partnership between the UK Biobank (UKB) and eight biopharmaceutical companies that …
Strategies to therapeutically modulate cytokine action
WJ Leonard, JX Lin - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …
functions, including development, differentiation, growth and survival. Accordingly, the …
Emerging topical and systemic JAK inhibitors in dermatology
F Solimani, K Meier, K Ghoreschi - Frontiers in immunology, 2019 - frontiersin.org
Accumulating data on cellular and molecular pathways help to develop novel therapeutic
strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic …
strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic …
New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology
MD Giraldez, D Carneros, C Garbers… - Nature reviews …, 2021 - nature.com
IL-6 family cytokines are defined by the common use of the signal-transducing receptor
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …
STAT3 signaling in immunity
EJ Hillmer, H Zhang, HS Li, SS Watowich - Cytokine & growth factor …, 2016 - Elsevier
The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases
Cytokines are major drivers of autoimmunity, and biologic agents targeting cytokines have
revolutionized the treatment of immune-mediated diseases. Despite the effectiveness of …
revolutionized the treatment of immune-mediated diseases. Despite the effectiveness of …