Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms
MC Liberman, SG Kujawa - Hearing research, 2017 - Elsevier
Common causes of hearing loss in humans-exposure to loud noise or ototoxic drugs and
aging-often damage sensory hair cells, reflected as elevated thresholds on the clinical …
aging-often damage sensory hair cells, reflected as elevated thresholds on the clinical …
Therapeutic potential of neurotrophins for repair after brain injury: a helping hand from biomaterials
J Houlton, N Abumaria, SFR Hinkley… - Frontiers in …, 2019 - frontiersin.org
Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …
in recovery. Significant effort has been made to try and minimize neuronal damage following …
Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma
Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory
neuron survival and establishment of neuronal projections to sensory epithelia in the …
neuron survival and establishment of neuronal projections to sensory epithelia in the …
Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure
In acquired sensorineural hearing loss, such as that produced by noise or aging, there can
be massive loss of the synaptic connections between cochlear sensory cells and primary …
be massive loss of the synaptic connections between cochlear sensory cells and primary …
Auditory-nerve responses to varied inter-phase gap and phase duration of the electric pulse stimulus as predictors for neuronal degeneration
After severe hair cell loss, secondary degeneration of spiral ganglion cells (SGCs) is
observed—a gradual process that spans years in humans but only takes weeks in guinea …
observed—a gradual process that spans years in humans but only takes weeks in guinea …
Scalar translocation comparison between lateral wall and perimodiolar cochlear implant arrays‐a meta‐analysis
S Jwair, A Prins, I Wegner, RJ Stokroos… - The …, 2021 - Wiley Online Library
Objectives/Hypothesis Two types of electrode arrays for cochlear implants (CIs) are
distinguished: lateral wall and perimodiolar. Scalar translocation of the array can lead to …
distinguished: lateral wall and perimodiolar. Scalar translocation of the array can lead to …
The role of BDNF as a biomarker in cognitive and sensory neurodegeneration
A Pisani, F Paciello, V Del Vecchio, R Malesci… - Journal of Personalized …, 2023 - mdpi.com
Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …
system and in sensory structures including olfactory and auditory systems. Many studies …
Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear
JL Pinyon, SF Tadros, KE Froud, AC Y. Wong… - Science translational …, 2014 - science.org
The cochlear implant is the most successful bionic prosthesis and has transformed the lives
of people with profound hearing loss. However, the performance of the “bionic ear” is still …
of people with profound hearing loss. However, the performance of the “bionic ear” is still …
New molecular therapies for the treatment of hearing loss
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …
loss is characterized by degeneration of key structures of the sensory pathway in the …
Importance of cochlear health for implant function
Amazing progress has been made in providing useful hearing to hearing-impaired
individuals using cochlear implants, but challenges remain. One such challenge is …
individuals using cochlear implants, but challenges remain. One such challenge is …