Preclinical studies coupled with clinical pharmacologic and neuroimaging investigations
have advanced our understanding of brain circuits that modulate pain. Descending pain …

Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Clonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well
as in chronic pain therapy because it has both anaesthetic and analgesic‐sparing activity …

The spinal cord is the first relay site in the transmission of nociceptive information from the
periphery to the brain. Sensory signals are transmitted from the periphery by primary afferent …

An expert working group of the European Association for Palliative Care has revised and
updated its guidelines on the use of morphine in the management of cancer pain. The …

Norepinephrine is involved in intrinsic control of pain. Main sources of norepinephrine are
sympathetic nerves peripherally and noradrenergic brainstem nuclei A1–A7 centrally …

The purpose of this review was to identify and analyze the controlled clinical trial data for
peripheral neuropathic pain (PNP) and complex regional pain syndromes (CRPS). A total of …

Opioids are our most powerful analgesics, but politics, prejudice, and our continuing
ignorance still impede optimum prescribing. Just over 100 years ago, opium poppies were …

ANESTHESIA has become remarkably safe, and while death and permanent damage have
become rare occurrences, other sequelae of anesthesia are gaining more importance …

This review summarizes recent findings on peripheral mechanisms underlying the
generation and inhibition of pain. The focus is on events occurring in peripheral injured …