Approach to the diagnosis and treatment of high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements

P Sesques, NA Johnson - Blood, The Journal of the American …, 2017 - ashpublications.org
High-grade B-cell lymphomas (HGBLs) with MYC and BCL2 and/or BCL6 rearrangements,
so-called “double-hit” lymphomas (HGBL-DH), are aggressive lymphomas that form a …

How I treat double-hit lymphoma

JW Friedberg - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
The 2016 revision of the World Health Organization (WHO) classification for lymphoma has
included a new category of lymphoma, separate from diffuse large B-cell lymphoma, termed …

Prognostication of diffuse large B-cell lymphoma in the molecular era: moving beyond the IPI

JC Wight, G Chong, AP Grigg, EA Hawkes - Blood reviews, 2018 - Elsevier
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with variable outcomes.
Despite the majority of patients being cured with combination chemoimmunotherapy, up to …

The spectrum of MYC alterations in diffuse large B-cell lymphoma

Y Xia, X Zhang - Acta haematologica, 2020 - karger.com
MYC, as a powerful transcription factor, plays a vital role in various cancers. The clinical
significance of MYC alterations in diffuse large B-cell lymphoma (DLBCL) has been …

MYC translocation and/or BCL 2 protein expression are associated with poor prognosis in diffuse large B‐cell lymphoma

K Kawamoto, H Miyoshi, N Yoshida… - Cancer …, 2016 - Wiley Online Library
Genomic alterations and protein expression levels have been established as prognostic
factors for survival in patients with diffuse large B‐cell lymphoma (DLBCL). In particular …

Further exploration of the complexities of large B-cell lymphomas with MYC abnormalities and the importance of a blastoid morphology

EM Moore, N Aggarwal, U Surti… - The American Journal of …, 2017 - journals.lww.com
Abstract The 2016 World Health Organization classification recognized “high-grade B-cell
lymphoma with MYC and BCL2 and/or BCL6 rearrangements”(double/triple-hit lymphoma …

Mean platelet volume as a predictive marker for venous thromboembolism and mortality in patients treated for diffuse large B‐cell lymphoma

J Rupa‐Matysek, L Gil, R Kroll‐Balcerzak… - Hematological …, 2017 - Wiley Online Library
It has been suggested that mean platelet volume (MPV) is associated with the risk of venous
thromboembolism (VTE) and increased mortality in patients with cancer. We evaluated the …

Double hit lymphoma: from biology to therapeutic implications

M Burotto, A Berkovits, K Dunleavy - Expert review of hematology, 2016 - Taylor & Francis
Introduction: Diffuse large B-cell lymphoma (DLBCL) is a molecularly heterogeneous
disease defined by different cellular origins and mechanisms of oncogenic activation …

An approach to small lymph node biopsies: pearls and pitfalls of reporting in the real world

A Shah, C Ross, M Sur - Journal of the American Society of Cytopathology, 2021 - Elsevier
Recent advances in interventional radiology have resulted in the utilization of small lymph
node biopsies, including fine-needle aspiration (FNA) and core needle biopsy (CNB) as an …

Contribution of immunophenotype to the investigation and differential diagnosis of Burkitt lymphoma, double‐hit high‐grade B‐cell lymphoma, and single‐hit MYC …

NJ Tsagarakis, SI Papadhimitriou… - Cytometry Part B …, 2020 - Wiley Online Library
Background There are no immunophenotypic guidelines for the investigation of MYC‐
rearranged lymphomas. We aimed to identify simple immunophenotypic features that would …