Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such
as palatable food, sexual activity and social interaction) and modulates the rewarding effects …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

Background and Purpose To evaluate the ability of cannabidiolic acid (CBDA) to reduce
nausea and vomiting and enhance 5‐HT1A receptor activation in animal models …

Food, drugs and brain stimulation can serve as strong rewarding stimuli and are all believed
to activate common brain circuits that evolved in mammals to favour fitness and survival. For …

The endogenous cannabinoid system is an important regulatory system involved in
physiological homeostasis. Endocannabinoid signaling is known to modulate neural …

Future therapies for diseases associated with altered dopaminergic signaling, including
Parkinson's disease, schizophrenia and drug addiction or drug dependence may …

Acute rewarding properties are essential for the establishment of cocaine addiction, and
multiple neurochemical processes participate in this complex behavior. In the present study …

Cannabidiol is a non‐psychotomimetic constituent of C annabis sativa, which induces
central effects in rodents. It has been shown that cannabidiol attenuates cue‐induced …

Adenosine–dopamine interactions in the central nervous system (CNS) have been studied
for many years in view of their relevance for disorders of the CNS and their treatments. The …

Abstract Δ9-tetrahydrocannabinol (Δ9-THC), the main psychoactive ingredient of marijuana,
has led to equivocal results when tested with the intracranial self-stimulation (ICSS) …