The p53 family of transcription factors is essential to counteract tumour formation and
progression. Although previously this was exclusively associated with the ability of the p53 …

Background & Aims We investigated the transcriptome of esophageal squamous cell
carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and …

Autophagy is a conserved catabolic process characterized by degradation and recycling of
cytosolic components or organelles through a lysosome-dependent pathway. It has a …

Distinct lung stem cells give rise to lung adenocarcinoma (LUAD) and squamous cell
carcinoma (LUSC). ΔNp63, the p53 family member and p63 isoform, guides the maturation …

As histone deacetylase inhibitors (HDACIs) have limited efficacy against solid tumors, we
investigated whether and how oxidative stress is involved in sensitivity to HDACIs to develop …

Background Epidermal growth factor receptor (EGFR) overexpression is associated with the
development of head and neck cancer (HNC) and represents one of the main therapeutic …

The p53 family member p63 exists as two major protein variants (TAp63 and ΔNp63) with
distinct expression patterns and functional properties. Whilst downstream target genes of …

The most frequent genetic alterations across multiple human cancers are mutations in TP53
and the activation of the PI3K/AKT pathway, two events crucial for cancer progression …

In precision cancer nanomedicine, the key is to identify the oncogenes that are responsible
for tumorigenesis, based on which these genetic drivers can be each specifically regulated …

Background Breast cancer, the most common cancer in women worldwide, causes the vast
majority of cancer-related deaths. Undoubtedly, tumor metastasis and recurrence are …