▪ Abstract Comparative modeling predicts the three-dimensional structure of a given protein
sequence (target) based primarily on its alignment to one or more proteins of known …

Major goal of structural biology involve formation of protein-ligand complexes; in which the
protein molecules act energetically in the course of binding. Therefore, perceptive of protein …

Comparative protein structure modeling predicts the three‐dimensional structure of a given
protein sequence (target) based primarily on its alignment to one or more proteins of known …

We describe a comparative protein modelling method designed to find the most probable
structure for a sequence given its alignment with related structures. The three dimensional …

We have developed a new scoring function, the template modeling score (TM‐score), to
assess the quality of protein structure templates and predicted full‐length models by …

Publisher Summary Functional characterization of a protein sequence is one of the most
frequent problems in biology. This task is usually facilitated by accurate three-dimensional …

Genome sequencing projects are producing linear amino acid sequences, but full
understanding of the biological role of these proteins will require knowledge of their …

Approximately one third of known protein sequences are related to at least one known
protein structure. As a result, an order of magnitude more sequences can be modeled by …

Comparative modelling of protein 3D structure can now be applied with reasonable
accuracy to ten times more protein sequences than the number of experimentally …

Abstract Knowledge, both from the three-dimensional structures of homologous proteins and
from the general analysis of protein structure, is of value in modeling a protein of known …