Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
mammalian brain, essential not only to the development of the central nervous system but …

Neuronal activity regulates the development and maturation of excitatory and inhibitory
synapses in the mammalian brain. Several recent studies have identified signalling …

Adult neuronal precursors retain the remarkable capacity to migrate long distances from the
posterior (subventricular zone) to the most anterior [olfactory bulb (OB)] parts of the brain …

A critical step in neuronal development is the formation of axon/dendrite polarity, a process
involving symmetry breaking in the newborn neuron. Local self-amplifying processes could …

A major goal of modern neuroscience research is to understand the cellular and molecular
processes that control the formation, function, and remodeling of chemical synapses. In this …

Many neurons resemble other cells in developing embryos in migrating long distances
before they differentiate. However, despite shared basic machinery, neurons differ from …

The distinctive morphology of neurons, with complex dendritic arbors and extensive axons,
presents spatial challenges for intracellular signal transduction. The endosomal system …

The ability of neurons to form a single axon and multiple dendrites underlies the directional
flow of information transfer in the central nervous system. Dendrites and axons are …

Angelman syndrome (AS) is a neurodevelopment disorder characterized by severe
cognitive impairment and a high rate of autism. AS is caused by disrupted neuronal …