Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease
TL Young-Pearse, H Lee, YC Hsieh, V Chou… - Trends in …, 2023 - cell.com
Alzheimer's disease (AD) manifests along a spectrum of cognitive deficits and levels of
neuropathology. Genetic studies support a heterogeneous disease mechanism, with around …
neuropathology. Genetic studies support a heterogeneous disease mechanism, with around …
Comprehensive evaluation of the 5XFAD mouse model for preclinical testing applications: a MODEL-AD study
The ability to investigate therapeutic interventions in animal models of neurodegenerative
diseases depends on extensive characterization of the model (s) being used. There are …
diseases depends on extensive characterization of the model (s) being used. There are …
[HTML][HTML] Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer's disease
DS Whittaker, L Akhmetova, D Carlin, H Romero… - Cell metabolism, 2023 - cell.com
Circadian disruptions impact nearly all people with Alzheimer's disease (AD), emphasizing
both their potential role in pathology and the critical need to investigate the therapeutic …
both their potential role in pathology and the critical need to investigate the therapeutic …
Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment
Background Human genetic association studies point to immune response and lipid
metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer's …
metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer's …
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease
Genetic association studies have demonstrated the critical involvement of the microglial
immune response in Alzheimer's disease (AD) pathogenesis. Phospholipase C-gamma-2 …
immune response in Alzheimer's disease (AD) pathogenesis. Phospholipase C-gamma-2 …
Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer's disease in a mouse model of Aβ amyloidosis
Recently, large-scale human genetics studies identified a rare coding variant in the ABI3
gene that is associated with an increased risk of Alzheimer's disease (AD). However …
gene that is associated with an increased risk of Alzheimer's disease (AD). However …
Omics-based biomarkers discovery for Alzheimer's disease
Q Aerqin, ZT Wang, KM Wu, XY He, Q Dong… - Cellular and Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorders presenting with
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …
Functional variants identify sex-specific genes and pathways in Alzheimer's Disease
The incidence of Alzheimer's Disease in females is almost double that of males. To search
for sex-specific gene associations, we build a machine learning approach focused on …
for sex-specific gene associations, we build a machine learning approach focused on …
Uncovering disease mechanisms in a novel mouse model expressing humanized APOEε4 and Trem2* R47H
Late-onset Alzheimer's disease (AD; LOAD) is the most common human neurodegenerative
disease, however, the availability and efficacy of disease-modifying interventions is severely …
disease, however, the availability and efficacy of disease-modifying interventions is severely …