Objective To investigate the therapeutic effect and mechanism of metformin on knee OA in
normal diet (ND) mice or high-fat diet (HFD)-induced obese mice. Methods Destabilization of …

Over the last several decades, a growing body of research has investigated the potential to
repurpose the anti-diabetic drug metformin for breast cancer prevention and/or treatment …

Background: Astragaloside IV (ASIV) is the primary pharmacologically active compound
found in Astragalus propinquus Schischkin, which has potential protective effects on cardiac …

Abstract G0/G1 switch gene 2 (G0S2) is known to inhibit lipolysis by inhibiting adipose
triglyceride lipase (ATGL). In this report, we dissect the role of G0S2 in ER+ versus ER …

Purpose Chemically induced acute lung injury (CALI) has become a serious health concern
in our industrialized world, and abnormal functional alterations of immune cells crucially …

Decidualization of human endometrial stromal cells (hESCs) is essential for the
maintenance of pregnancy, which depends on the fine-tuned regulation of hESCs survival …

Breast cancer has the second highest cancer mortality rate in women in the United States.
While current treatments have significantly improved patient outlook, breast cancer patients …