The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous
human suffering. To date, no effective drug is available to directly treat the disease. In a …

There is accumulating evidence demonstrating that dysfunction of glutamatergic
neurotransmission, particularly via N-methyl-d-aspartate (NMDA) receptors, is involved in …

Highlights•The NMDA receptor is a membrane protein critical to mammalian learning and
memory.•Heterotetrameric NMDARs consist of three structured domains that regulate ion …

Long-term alcohol exposure may lead to development of alcohol dependence in
consequence of altered neurotransmitter functions. Accumulating evidence suggests that the …

N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that play key
roles in brain physiology and pathology. Because numerous pathologic conditions involve …

Parkinson's disease is a debilitating neurodegenerative movement disorder that is the result
of a degeneration of dopaminergic neurons in the substantia nigra pars compacta. The …

In the present study, the hypothesis that sex-related differences in glutamate-evoked rat
masseter muscle afferent discharge may result from estrogen-related modulation of …

The quest for NR2B subtype selective NMDA antagonists started almost twenty years ago.
The structure of ifenprodil, the prototype of this group of compounds, inspired many …

Ifenprodil (1) is a potent GluN2B-selective N-methyl-d-aspartate (NMDA) receptor antagonist
that is used as a cerebral vasodilator and has been examined in clinical trials for the …

Synaptodendritic damage correlates with cognitive decline in many neurodegenerative
diseases, including human immunodeficiency virus-1 (HIV-1)-associated neurocognitive …