Diabetes Mellitus Type II (DM2) is a growing international health concern with no end in
sight. Complications of DM2 involve a myriad of comorbidities including the serious …

Following a skin injury, the damaged tissue is repaired through the coordinated biological
actions that constitute the cutaneous healing response. In mammals, repaired skin is not …

Chronic diabetic wounds represent a huge socioeconomic burden for both affected
individuals and the entire healthcare system. Although the number of available treatment …

In wound healing, a variety of mediators have been identified throughout the years. The
mediators discussed here comprise growth factors, cytokines and chemokines. These …

Delayed wound healing is one of the major therapeutic and economic issues in medicine
today. Cutaneous wound healing is an extremely well-regulated and complex process …

Activation of sonic hedgehog (Shh) signaling has been implicated in progression of a variety
of tumors. In this study, we elucidated a role for Shh in the invasion of gastric tumors and …

Skin injuries and chronic non-healing wounds are one of the major global burdens on the
healthcare systems worldwide due to their difficult-to-treat nature, associated co-morbidities …

Studies regarding macroautophagic/autophagic regulation in endothelial cells (ECs) under
diabetic conditions are very limited. Clinical evidence establishes an endothelial protective …

Skin injuries and in particular, chronic wounds, are one of the major prevalent medical
problems, worldwide. Due to the pivotal role of angiogenesis in tissue regeneration …

There is a clinical need for new, more effective treatments for chronic wounds in diabetic
patients. Lack of epithelial cell migration is a hallmark of nonhealing wounds, and diabetes …