The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …

INTRODUCTION Cytoplasmic face of the human NPC. Near-atomic composite structure of
the NPC generated by docking high-resolution crystal structures into a cryo‑ET …

Delivering the virus genome into the host nucleus through the nuclear pore complex (NPC)
is pivotal in human immunodeficiency virus 1 (HIV-1) infection. The mechanism of this …

Increasing evidence has suggested that the HIV-1 capsid enters the nucleus in a largely
assembled, intact form. However, not much is known about how the cone-shaped capsid …

HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving
functional interactions between the capsid protein (CA) and nucleoporins (Nups). Here, we …

The HIV-1 capsid, composed of approximately 1,200 copies of the capsid protein, encases
genomic RNA alongside viral nucleocapsid, reverse transcriptase, and integrase proteins …

After invasion of a susceptible target cell, HIV-1 completes the early phase of its life cycle
upon integration of reverse-transcribed viral DNA into host chromatin. The viral capsid, a …

Oncogenic tyrosine kinase fusions involving the anaplastic lymphoma kinase (ALK) are
detected in numerous tumor types. Although more than 30 distinct 5′ fusion partner genes …

Retroviruses integrate their reverse transcribed genomes into host cell chromosomes as an
obligate step in virus replication. The nuclear envelope separates the chromosomes from …