Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …

Congenital melanocytic naevi (CMN) are a known risk factor for melanoma, with the greatest
risk currently thought to be in childhood. There has been controversy over the years about …

Large and giant congenital melanocytic nevi (CMN) are rare melanocytic lesions mostly
caused by postzygotic NRAS alteration. Molecular characterization is usually focused on …

Primary melanocytic tumors of the central nervous system (CNS) represent a spectrum of
rare tumors. They can be benign or malignant and occur in adults as well as in children, the …

Background Genotype–phenotype studies can identify subgroups of patients with specific
clinical features or differing outcomes, which can help shape management. Objectives To …

Giant congenital nevi are melanocytic proliferations of the skin that may be complicated by
melanoma, neurocutaneous melanocytosis, pain, pruritus, and disfigurement. Current …

In daily clinical practice melanocytic nevi are commonly encountered. Traditionally, both
benign and malignant melanocytic tumors have been sub-classified by their histopathologic …

Patients with large and giant CMN should be managed by an interdisciplinary care team for
the monitoring of dermatologic, neurologic, and psychosocial concerns. Ongoing research is …

Oculoectodermal syndrome (OES) and encephalocraniocutaneous lipomatosis (ECCL) are
rare disorders that share many common features, such as epibulbar dermoids, aplasia cutis …

The incidence of melanoma, the most lethal form of skin cancer, has increased due to
ultraviolet exposure. The treatment of advanced melanoma, particularly metastatic cases …