Anticancer agents are critical for the cancer treatment, but side effects and the drug
resistance associated with the currently used anticancer agents create an urgent need to …

Triazole moiety which is usually constructed by highly versatile, efficacious and selective
copper-catalyzed azide-alkyne cycloaddition not only can act as a linker to connect different …

Nicotinamide adenine dinucleotide (NAD) is a cofactor of many enzymatic reactions as well
as being a substrate for a number of NAD-consuming enzymes (eg, PARPS, sirtuins, etc) …

Highlights•NAMPT is overexpressed in cancers, associating with a poor prognosis and
tumor progression.•Extensive efforts have been made to improve efficacy and safety of early …

Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a
substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and …

Alzheimer's disease (AD) is the principal cause of dementia, and its incidence increases
with age. Altered antioxidant systems and inflammation have an important role in the …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common and
devastating clinical disorders with high mortality and no specific therapy …

Nicotinamide phosphoribosyltransferase (NAMPT) is the bottleneck enzyme of the NAD
salvage pathway and thereby is a controller of intracellular NAD concentrations. It has been …

Endometriosis is a gynecological condition affecting patients in reproductive age. The aim of
this paper was to assess the effects of the autophagy and mitophagy induction in a rat model …

Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in
tumor-bearing mice the macrophage colony-stimulating factor elevates the myeloid cell …