Recent theoretical accounts have proposed excitation and inhibition (E/I) imbalance as a
possible mechanistic, network-level hypothesis underlying neural and behavioral …

Background Low-frequency (delta/theta) oscillations in the thalamocortical system are
elevated in schizophrenia during wakefulness and are also induced in the N-methyl-D …

In recent years, schizophrenia research has focused on inhibitory interneuron dysfunction at
the level of neurobiology and on cognitive impairments at the psychological level …

Background We sought to examine resting-state functional magnetic resonance imaging
connectivity measures in psychotic patients to both identify cumulative differences across …

Perineuronal nets (PNNs) are enigmatic structures composed of extracellular matrix
molecules that encapsulate the soma, dendrites, and axon segments of neurons in a lattice …

Brain activity derives from intrinsic dynamics (due to neurophysiology and anatomical
connectivity) in concert with stochastic effects that arise from sensory fluctuations, brainstem …

Background Working memory (WM) deficits are a core feature of schizophrenia.
Electrophysiological studies suggest that impaired early visual processing may contribute to …

Exploratory data-driven studies of brain networks have become the object of much
neuroimaging research in psychiatry, alongside classic approaches that probe regional …

One of the challenges facing translational neuroscience is to achieve a deep understanding
of how brain circuits represent behavior and the clinical features of psychiatric disorders …

Excessive variability in behavioral performance and neuronal activation is a common finding
in studies of schizophrenia. Recent evidence suggests that this may be due to an imbalance …