The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …

Central nervous system (CNS) disorders are a therapeutic area in drug discovery where
demand for new treatments greatly exceeds approved treatment options. This is complicated …

Pain and nociception are different phenomena. Nociception is the result of complex activity
in sensory pathways. On the other hand, pain is the effect of interactions between …

Specialized proresolving mediators (SPMs) have demonstrated potent analgesic actions in
animal models of pathological pain. The actions of SPMs in acute and chronic itch are …

Background Paclitaxel is a taxane-based chemotherapeutic agent used as a treatment in
breast cancer. There is no effective prevention or treatment strategy for the most common …

Voltage‐gated sodium channels (VGSCs/Navs), which control the flow of Na+ and affect the
generation of action potentials (APs), have been regarded as essential targets for many …

The resolution of inflammation is a biosynthetically active process controlled by the interplay
between oxygenated polyunsaturated mediators and G-protein coupled receptor-signaling …

Histone deacetylases (HDACs) are overexpressed in cancer, and their inhibition shows
promising results in cancer therapy. In particular, selective class I HDAC inhibitors such as …

Activation of neuraxial nociceptive linkages leads to a high level of encoding of the message
that is transmitted to the brain and that can initiate a pain state with its attendant emotive …

Specialized pro-resolving mediators (SPMs) have demonstrated potent analgesic actions in
animal models of pathological pain. The actions of SPMs in acute and chronic itch are …