Neuropathic pain: mechanisms, sex differences, and potential therapies for a global problem
S Ghazisaeidi, MM Muley… - Annual Review of …, 2023 - annualreviews.org
The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …
Computer-aided drug design towards new psychotropic and neurological drugs
Central nervous system (CNS) disorders are a therapeutic area in drug discovery where
demand for new treatments greatly exceeds approved treatment options. This is complicated …
demand for new treatments greatly exceeds approved treatment options. This is complicated …
Pathophysiology of nociception and rare genetic disorders with increased pain threshold or pain insensitivity
M Cascella, MR Muzio, F Monaco, D Nocerino… - Pathophysiology, 2022 - mdpi.com
Pain and nociception are different phenomena. Nociception is the result of complex activity
in sensory pathways. On the other hand, pain is the effect of interactions between …
in sensory pathways. On the other hand, pain is the effect of interactions between …
Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic …
Specialized proresolving mediators (SPMs) have demonstrated potent analgesic actions in
animal models of pathological pain. The actions of SPMs in acute and chronic itch are …
animal models of pathological pain. The actions of SPMs in acute and chronic itch are …
Neuro-immune interactions in paclitaxel-induced peripheral neuropathy
CJC Vermeer, AE Hiensch, L Cleenewerk… - Acta …, 2021 - Taylor & Francis
Background Paclitaxel is a taxane-based chemotherapeutic agent used as a treatment in
breast cancer. There is no effective prevention or treatment strategy for the most common …
breast cancer. There is no effective prevention or treatment strategy for the most common …
Recent advances in computational studies on voltage‐gated sodium channels: Drug design and mechanism studies
G Wang, L Xu, H Chen, Y Liu, P Pan… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Voltage‐gated sodium channels (VGSCs/Navs), which control the flow of Na+ and affect the
generation of action potentials (APs), have been regarded as essential targets for many …
generation of action potentials (APs), have been regarded as essential targets for many …
A new synthetic protectin D1 analog 3-oxa-PD1 n-3 DPA reduces neuropathic pain and chronic itch in mice
The resolution of inflammation is a biosynthetically active process controlled by the interplay
between oxygenated polyunsaturated mediators and G-protein coupled receptor-signaling …
between oxygenated polyunsaturated mediators and G-protein coupled receptor-signaling …
Development of New Inhibitors of HDAC1–3 Enzymes Aided by In Silico Design Strategies
N Cheshmazar, S Hemmati… - Journal of Chemical …, 2022 - ACS Publications
Histone deacetylases (HDACs) are overexpressed in cancer, and their inhibition shows
promising results in cancer therapy. In particular, selective class I HDAC inhibitors such as …
promising results in cancer therapy. In particular, selective class I HDAC inhibitors such as …
[HTML][HTML] Neuraxial drug delivery in pain management: an overview of past, present, and future
TL Yaksh, GG Dos Santos, JBP Lemes… - Best Practice & Research …, 2023 - Elsevier
Activation of neuraxial nociceptive linkages leads to a high level of encoding of the message
that is transmitted to the brain and that can initiate a pain state with its attendant emotive …
that is transmitted to the brain and that can initiate a pain state with its attendant emotive …
[HTML][HTML] Novel pro-resolving lipid mediator mimetic 3-oxa-PD1n-3 DPA reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission …
Specialized pro-resolving mediators (SPMs) have demonstrated potent analgesic actions in
animal models of pathological pain. The actions of SPMs in acute and chronic itch are …
animal models of pathological pain. The actions of SPMs in acute and chronic itch are …