The calcium–cancer signalling nexus
GR Monteith, N Prevarskaya… - Nature Reviews …, 2017 - nature.com
The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …
outcomes. Cellular machinery important in tumour progression is often driven or influenced …
[HTML][HTML] Altered calcium signaling in cancer cells
TA Stewart, KTDS Yapa, GR Monteith - Biochimica et Biophysica Acta (BBA …, 2015 - Elsevier
It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …
Targeting EMT in cancer: opportunities for pharmacological intervention
The spread of cancer cells to distant organs represents a major clinical challenge in the
treatment of cancer. Epithelial–mesenchymal transition (EMT) has emerged as a key …
treatment of cancer. Epithelial–mesenchymal transition (EMT) has emerged as a key …
Induction of epithelial–mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent
Signals from the tumor microenvironment trigger cancer cells to adopt an invasive
phenotype through epithelial–mesenchymal transition (EMT). Relatively little is known …
phenotype through epithelial–mesenchymal transition (EMT). Relatively little is known …
Purinergic signalling and cancer
G Burnstock, F Di Virgilio - Purinergic signalling, 2013 - Springer
Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …
mediate a large array of responses ranging from growth stimulation to apoptosis, from …
CX3CR1 acts as a protective biomarker in the tumor microenvironment of colorectal cancer
Y Yue, Q Zhang, Z Sun - Frontiers in immunology, 2022 - frontiersin.org
The tumor microenvironment (TME) plays an important role in the pathogenesis of many
cancers. We aimed to screen the TME-related hub genes of colorectal adenoma (CRAD) …
cancers. We aimed to screen the TME-related hub genes of colorectal adenoma (CRAD) …
Calcium influx pathways in breast cancer: opportunities for pharmacological intervention
I Azimi, SJ Roberts‐Thomson… - British journal of …, 2014 - Wiley Online Library
Ca2+ influx through Ca2+ permeable ion channels is a key trigger and regulator of a diverse
set of cellular events, such as neurotransmitter release and muscle contraction. Ca2+ influx …
set of cellular events, such as neurotransmitter release and muscle contraction. Ca2+ influx …
The calcium-signaling toolkit in cancer: remodeling and targeting
SJ Roberts-Thomson… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Processes that are important in cancer progression, such as sustained cell growth, invasion
to other organs, and resistance to cell death inducers, have a clear overlap with pathways …
to other organs, and resistance to cell death inducers, have a clear overlap with pathways …
P2X7 receptor stimulates breast cancer cell invasion and migration via the AKT pathway
J Xia, X Yu, L Tang, G Li, T He - Oncology reports, 2015 - spandidos-publications.com
Purinergic signaling has been implicated in the regulation of many cellular processes. A
high concentration of ATP has been observed in the tumor microenvironment, suggesting a …
high concentration of ATP has been observed in the tumor microenvironment, suggesting a …
P2Y2 receptor promotes cell invasion and metastasis in prostate cancer cells
WH Li, Y Qiu, HQ Zhang, Y Liu, JF You, XX Tian… - British journal of …, 2013 - nature.com
Background: Our previous study demonstrated that extracellular adenosine 5′-triphosphate
(ATP) stimulated prostate cancer cell invasion via P2Y receptors. However, the purinergic …
(ATP) stimulated prostate cancer cell invasion via P2Y receptors. However, the purinergic …