The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …

It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …

The spread of cancer cells to distant organs represents a major clinical challenge in the
treatment of cancer. Epithelial–mesenchymal transition (EMT) has emerged as a key …

Signals from the tumor microenvironment trigger cancer cells to adopt an invasive
phenotype through epithelial–mesenchymal transition (EMT). Relatively little is known …

Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

The tumor microenvironment (TME) plays an important role in the pathogenesis of many
cancers. We aimed to screen the TME-related hub genes of colorectal adenoma (CRAD) …

Ca2+ influx through Ca2+ permeable ion channels is a key trigger and regulator of a diverse
set of cellular events, such as neurotransmitter release and muscle contraction. Ca2+ influx …

Processes that are important in cancer progression, such as sustained cell growth, invasion
to other organs, and resistance to cell death inducers, have a clear overlap with pathways …

Purinergic signaling has been implicated in the regulation of many cellular processes. A
high concentration of ATP has been observed in the tumor microenvironment, suggesting a …

Background: Our previous study demonstrated that extracellular adenosine 5′-triphosphate
(ATP) stimulated prostate cancer cell invasion via P2Y receptors. However, the purinergic …