Antibodies against angiotensin II type 1 and endothelin A receptors: relevance and pathogenicity

MC Philogene, T Johnson, AJ Vaught, S Zakaria… - Human immunology, 2019 - Elsevier
Antibodies against two G-protein coupled receptors (GPCRs), angiotensin II type 1 receptor
(AT1R) and endothelin A receptor (ETAR) are among a growing number of autoantibodies …

[HTML][HTML] A comprehensive overview of the clinical relevance and treatment options for antibody-mediated rejection associated with non-HLA antibodies

T Kardol-Hoefnagel, HG Otten - Transplantation, 2021 - journals.lww.com
Although solid organ transplant results have improved significantly in recent decades, a
pivotal cause of impaired long-term outcome is the development of antibody-mediated …

Early effects of first‐line treatment with anti‐interleukin‐6 receptor antibody tocilizumab for chronic active antibody‐mediated rejection in kidney transplantation

A Lavacca, R Presta, C Gai, A Mella… - Clinical …, 2020 - Wiley Online Library
Introduction Chronic active antibody‐mediated rejection (cAMR) is a major determinant of
late allograft failure. Rituximab/immunoglobulins (IVIg)+ plasma exchange (PLEX) showed …

Pre-transplant screening for non-HLA antibodies: who should be tested?

MC Philogene, S Zhou, BE Lonze, S Bagnasco… - Human immunology, 2018 - Elsevier
Retrospective studies of angiotensin II type 1 receptor antibodies (AT1R-Ab) and anti-
endothelial cell antibodies (AECA) have linked these antibodies to allograft injury. Because …

A 2020 Banff Antibody‐mediatedInjury Working Group examination of international practices for diagnosing antibody‐mediated rejection in kidney transplantation–a …

CA Schinstock, M Askar, SM Bagnasco… - Transplant …, 2021 - Wiley Online Library
The Banff antibody‐mediated rejection (ABMR) classification is vulnerable to
misinterpretation, but the reasons are unclear. To better understand this vulnerability, we …

Antigen and cell-based assays for the detection of non-HLA antibodies

RGM Lammerts, D Altulea, BG Hepkema… - Frontiers in …, 2022 - frontiersin.org
To date, human leukocyte antigens (HLA) have been the major focus in the approach to
acute and chronic antibody-mediated rejection (AMBR) in solid-organ transplantation …

B-cell response in solid organ transplantation

SG Yi, AO Gaber, W Chen - Frontiers in Immunology, 2022 - frontiersin.org
The transcriptional regulation of B-cell response to antigen stimulation is complex and
involves an intricate network of dynamic signals from cytokines and transcription factors …

Assessment and management of allosensitization following heart transplant in adults

A Jaiswal, J Bell, EM DeFilippis, EP Kransdorf… - The Journal of Heart and …, 2023 - Elsevier
Immunological injury to the allograft, specifically by antibodies to de novo donor specific
human leukocyte antigen (dn DSA) and antibody mediated injury and rejection are the major …

Sensitization to endothelial cell antigens: unraveling the cause or effect paradox

AM Jackson, M Delville, B Lamarthée, D Anglicheau - Human Immunology, 2019 - Elsevier
Anti-endothelial cell antibodies (AECAs) have been correlated with increased acute and
chronic rejection across all organ types and early graft dysfunction in kidney and heart …

Angiotensin II type 1 receptor antibody-mediated rejection following orthotopic heart transplant: a single-center experience

JD Moreno, AK Verma, BJ Kopecky, C Dehner… - …, 2022 - journals.lww.com
Background. Antibody-mediated rejection (AMR) following orthotopic heart transplant (OHT)
causes significant morbidity and mortality. There are limited data on antibodies to the …