A complete understanding of DNA double-helical structure discovered by James Watson
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …

Naturally, in somatic cells chromosome ends (telomeres) shorten during each cell division.
This process ensures to limit proliferation of somatic cells to avoid malignant proliferation; …

Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …

Guanine-rich DNA sequences can fold into stable four-stranded structures called G-
quadruplexes or G4s. Research in the past decade demonstrated that G4 structures are …

Alternative DNA structures that differ from the canonical B-form of DNA can arise from
repetitive sequences and play beneficial roles in many cellular processes such as gene …

The formation of G-quadruplex structures (G4s) in vitro from guanine (G)-rich nucleic acid
sequences of DNA and RNA stabilized with monovalent cations, typically K+ and Na+, under …

Simple Summary Gallic acid, a natural phenolic compound in diet, interacts with DNA G-
quadruplexes both in vitro and in vivo. In particular, gallic acid targets G-quadruplexes in …

The development of triple-negative breast cancer (TNBC) is highly associated with G-
quadruplex (G4); thus, targeting G4 is a potential strategy for TNBC therapy. Because …

The B-MYB gene encodes a transcription factor (B-MYB) that regulates cell growth and
survival. Abnormal expression of B-MYB is frequently observed in lung cancer and poses …

The nucleolus is the largest membraneless organelle and nuclear body in mammalian cells.
It is primarily involved in the biogenesis of ribosomes, essential macromolecular machines …