Overcoming Soluble Target Interference in Measurement of Total Bispecific Therapeutic Antibody Concentrations
J Shim, J Chen, M Carrasco-Triguero, SK Fischer - The AAPS Journal, 2023 - Springer
The measurement of therapeutic drug concentrations is used to assess drug exposure and
the relationship between therapeutic pharmacokinetics (PK) and pharmacodynamics (PD) …
the relationship between therapeutic pharmacokinetics (PK) and pharmacodynamics (PD) …
A generic anti-drug antibody assay for monoclonal antibody therapeutics with broad dynamic range eliminates the need for titer evaluation in preclinical studies
H Li, AR Foley, J Shim, K Siradze… - … of Pharmaceutical and …, 2024 - Elsevier
In preclinical protein therapeutic development studies, the emergence of anti-drug
antibodies (ADA) can potentially impact drug pharmacokinetics and safety. While …
antibodies (ADA) can potentially impact drug pharmacokinetics and safety. While …
[HTML][HTML] Sialic Acid Mediated Endothelial and Hepatic Uptake: A Mechanism based Mathematic Model Elucidating the Complex Pharmacokinetics and …
Sialic acid (SA) is crucial for protecting glycoproteins from clearance. Efmarodocokin alfa (IL-
22Fc), a fusion protein agonist that links IL-22 to the crystallizable fragment (Fc) of human …
22Fc), a fusion protein agonist that links IL-22 to the crystallizable fragment (Fc) of human …
[引用][C] Anti-KLK5/KLK7 Antibody-based Strategies for the Treatment of Epidermal Diseases
G Pampalakis - Current Pharmaceutical Design, 2023 - ingentaconnect.com
The epidermis is the physical barrier between the human body and the environment and
consists of four layers: the stratum basale, the stratum spinosum, the stratum granulosum …
consists of four layers: the stratum basale, the stratum spinosum, the stratum granulosum …