SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides

L Gorecki, J Korabecny, K Musilek, D Malinak… - Archives of …, 2016 - Springer
Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many
failures in living organism and ultimately in death. Organophosphorus compounds …

Development and structural modifications of cholinesterase reactivators against chemical warfare agents in last decade: a review

R Sharma, B Gupta, N Singh… - Mini Reviews in …, 2015 - ingentaconnect.com
Organophosphate (OP) pesticides and nerve agents are responsible for suicidal and
accidental poisonings. The acute toxicity of nerve agents leads to progressive inhibition of …

The experimental oxime K027—a promising protector from organophosphate pesticide poisoning. A review comparing K027, K048, pralidoxime, and obidoxime

DE Lorke, GA Petroianu - Frontiers in neuroscience, 2019 - frontiersin.org
Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide.
Standard therapy with atropine and established oxime-type enzyme reactivators …

A new post-intoxication treatment of paraoxon and parathion poisonings using an evolved PON1 variant and recombinant GOT1

M Goldsmith, Y Ashani, R Margalit, A Nyska… - Chemico-Biological …, 2016 - Elsevier
Organophosphate (OP) based pesticides are highly toxic compounds that are still widely
used in agriculture around the world. According to World Health Organization (WHO) data, it …

Oxime K203: a drug candidate for the treatment of tabun intoxication

L Gorecki, O Soukup, T Kucera, D Malinak, D Jun… - Archives of …, 2019 - Springer
For over 60 years, researchers across the world have sought to deal with poisoning by nerve
agents, the most toxic and lethal chemical weapons. To date, there is no efficient causal …

Facile and visual detection of acetylcholinesterase inhibitors by carbon quantum dots

B Gupta, R Sharma, KK Ghosh - New Journal of Chemistry, 2019 - pubs.rsc.org
Sensitive and rapid detection of organophosphate toxicants is highly relevant and important
in environmental protection and food safety. Owing to this, a carbon quantum dot (CQD) …

Preferential Door for Ligand Binding and Unbinding Pathways in Inhibited Human Acetylcholinesterase

N Kongkaew, K Hengphasatporn… - The Journal of …, 2024 - ACS Publications
Rising global population and increased food demands have resulted in the increased use of
organophosphate pesticides (OPs), leading to toxin accumulation and transmission to …

Drosophila melanogaster as a model organism for screening acetylcholinesterase reactivators

PE Macedo, JES Batista, LR Souza… - Journal of Toxicology …, 2024 - Taylor & Francis
The widely used insecticide chlorpyrifos (CP) is known to inhibit acetylcholinesterase
(AChE) activity attributed to result in various neurological disorders and acetylcholine …

Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents

E Prchalova, R Andrys, J Pejchal, Z Kohoutova… - Archives of …, 2024 - Springer
Six novel brominated bis-pyridinium oximes were designed and synthesized to increase
their nucleophilicity and reactivation ability of phosphorylated acetylcholinesterase (AChE) …

Synthesis and in-vitro reactivation screening of imidazolium aldoximes as reactivators of sarin and VX-inhibited human acetylcholinesterase (hAChE)

R Sharma, B Gupta, AK Sahu, J Acharya… - Chemico-biological …, 2016 - Elsevier
Post-treatment of organophosphate (OP) poisoning involves the application of oxime
reactivator as an antidote. Structurally different oximes are widely studied to examine their …