Pre-eclampsia is a multisystem pregnancy disorder characterised by variable degrees of
placental malperfusion, with release of soluble factors into the circulation. These factors …

The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …

Early-onset preeclampsia has been linked to poor placentation and fetal growth restriction,
whereas late-onset preeclampsia was suggested to result from maternal factors. We have …

Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a
successful placentation and normal placental function. It is an intricate process that involves …

Gestational diabetes mellitus (GDM) traditionally refers to abnormal glucose tolerance with
onset or first recognition during pregnancy. GDM has long been associated with obstetric …

Background: Effective screening for term preeclampsia is provided by a combination of
maternal factors with measurements of mean arterial pressure, serum placental growth …

Systemic manifestation of preeclampsia (PE) is associated with circulating factors, including
inflammatory cytokines and damage-associated molecular patterns (DAMPs), or alarmins …

The mechanistic properties of two dietary antioxidants that are required by humans, vitamins
C and E, are discussed relative to their biological effects. Vitamin C (ascorbic acid) is an …

Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic
cardiovascular disease. These medications not only reduce low-density lipoprotein …

Objective There is discrepancy in the literature on the definitions of severe and early-onset
pre-eclampsia. We aimed to determine those definitions for clinical purposes and to …