Advances in mechanical biomarkers

M Eroles, F Rico - Journal of Molecular Recognition, 2023 - Wiley Online Library
Mechanical biomarkers distinguish health conditions through quantitative mechanical
measurements. The emergence and establishment of nanotechnology in the last decades …

Advancements in Mid-Infrared spectroscopy of extracellular vesicles

R Di Santo, B Niccolini, S Romanò, M Vaccaro… - … Acta Part A: Molecular …, 2024 - Elsevier
Extracellular vesicles (EVs) are lipid vesicles secreted by all cells into the extracellular
space and act as nanosized biological messengers among cells. They carry a specific …

[HTML][HTML] Exploring novel circulating biomarkers for liver cancer through extracellular vesicle characterization with infrared spectroscopy and plasmonics

R Di Santo, F Verdelli, B Niccolini, S Varca… - Analytica Chimica …, 2024 - Elsevier
Background Hepatocellular carcinoma (HCC) is the most common form of liver cancer, with
cirrhosis being a major risk factor. Traditional blood markers like alpha-fetoprotein (AFP) …

Label-free digital holotomography reveals ibuprofen-induced morphological changes to red blood cells

T Bergaglio, S Bhattacharya, D Thompson… - ACS nanoscience …, 2023 - ACS Publications
Understanding the dose-dependent effect of over-the-counter drugs on red blood cells
(RBCs) is crucial for hematology and digital pathology. Yet, it is challenging to continuously …

Acceleration of the development of microcirculation embolism in the brain due to capillary narrowing

J Murata, M Unekawa, Y Kudo, M Kotani, I Kanno… - Stroke, 2023 - Am Heart Assoc
BACKGROUND: Cerebral microvascular obstruction is critically involved in recurrent stroke
and decreased cerebral blood flow with age. The obstruction must occur in the capillary with …

[HTML][HTML] Sensing Biomechanical Alterations in Red Blood Cells of Type 1 Diabetes Patients: Potential Markers for Microvascular Complications

R Di Santo, B Niccolini, A Rizzi, L Bertini, DP Marafon… - Biosensors, 2024 - mdpi.com
In physiological conditions, red blood cells (RBCs) demonstrate remarkable deformability,
allowing them to undergo considerable deformation when passing through the …

Reconsidering red blood cells as the diagnostic potential for neurodegenerative disorders

S Yadav, Deepika, K Moar, A Kumar, N Khola… - Biology of the …, 2024 - Wiley Online Library
Abstract Background Red blood cells (RBCs) are usually considered simple cells and
transporters of gases to tissues. Hypothesis However, recent research has suggested that …

Optical discrimination of pathological red blood cells

M Vergari, B Niccolini, D Pitocco, A Rizzi… - Biotechnology and …, 2024 - Wiley Online Library
Fast diagnostic methods are crucial to reduce the burden on healthcare systems. Currently,
detection of diabetes complications such as neuropathy requires time‐consuming …

Atomic force microscopy in disease‐related studies: Exploring tissue and cell mechanics

S Liu, Y Han, L Kong, G Wang… - Microscopy Research and …, 2024 - Wiley Online Library
Despite significant progress in human medicine, certain diseases remain challenging to
promptly diagnose and treat. Hence, the imperative lies in the development of more …

[PDF][PDF] Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies

DS Prudinnik, A Kussanova, IA Vorobjev… - Aging and …, 2025 - researchgate.net
Aging is interrelated with changes in red blood cell parameters and functionality. In this
article, we focus on red blood cells (RBCs) and provide a review of the known changes …