Phenotypic approaches to obstructive sleep apnoea–new pathways for targeted therapy

DJ Eckert - Sleep medicine reviews, 2018 - Elsevier
People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

International consensus statement on obstructive sleep apnea

JL Chang, AN Goldberg, JA Alt… - International forum of …, 2023 - Wiley Online Library
Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

European position paper on drug-induced sedation endoscopy (DISE)

A De Vito, M Carrasco Llatas, A Vanni, M Bosi… - Sleep and …, 2014 - Springer
Background Although drug-induced sedation endoscopy (DISE) represents the most
widespread diagnostic tool for upper airway endoscopic evaluation of snoring and …

The effects of anesthesia and opioids on the upper airway: a systematic review

Z Ehsan, M Mahmoud, SR Shott, RS Amin… - The …, 2016 - Wiley Online Library
Objectives/Hypothesis Drug‐induced sleep endoscopy (DISE) is used to determine surgical
therapy for obstructive sleep apnea (OSA); however, the effects of anesthesia on the upper …

Anatomical determinants of upper airway collapsibility in obstructive sleep apnea: a systematic review and meta-analysis

PJ Hartfield, J Janczy, A Sharma, HA Newsome… - Sleep Medicine …, 2023 - Elsevier
Upper airway (UA) collapsibility is one of the key factors that determine the severity of
obstructive sleep apnea (OSA). Interventions for OSA are aimed at reducing UA …

Upper airway collapsibility is associated with obesity and hyoid position

PR Genta, F Schorr, DJ Eckert, E Gebrim, F Kayamori… - Sleep, 2014 - academic.oup.com
Abstract Study Objectives: Upper airway anatomy plays a major role in obstructive sleep
apnea (OSA) pathogenesis. An inferiorly displaced hyoid as measured by the mandibular …

Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold

DJ Eckert, A Malhotra, A Wellman, DP White - Sleep, 2014 - academic.oup.com
Abstract Study Objectives: The effect of common sedatives on upper airway physiology and
breathing during sleep in obstructive sleep apnea (OSA) has been minimally studied …

A novel model to estimate key obstructive sleep apnea endotypes from standard polysomnography and clinical data and their contribution to obstructive sleep apnea …

R Dutta, G Delaney, B Toson, AS Jordan… - Annals of the …, 2021 - atsjournals.org
Rationale: There are at least four key pathophysiological endotypes that contribute to
obstructive sleep apnea (OSA) pathophysiology. These include 1) upper-airway …

Critical to know Pcrit: a review on pharyngeal critical closing pressure in obstructive sleep apnea

E Kazemeini, E Van de Perck, M Dieltjens… - Frontiers in …, 2022 - frontiersin.org
It is crucial to understand the underlying pathophysiology of obstructive sleep apnea (OSA).
Upper airway collapsibility is an important pathophysiological factor that affects the upper …

Obstructive sleep apnoea pathogenesis from mild to severe: Is it all the same?

BA Edwards, DJ Eckert, AS Jordan - Respirology, 2017 - Wiley Online Library
Obstructive sleep apnoea (OSA) is a common disorder caused by not only an impaired
upper airway anatomy (ie anatomically narrow/collapsible airway), but also by several non …