Mucosal and cutaneous human papillomavirus infections and cancer biology

T Gheit - Frontiers in Oncology, 2019 - frontiersin.org
Papillomaviridae is a family of small non-enveloped icosahedral viruses with double-
stranded circular DNA. More than 200 different human papillomaviruses (HPVs) have been …

The biology of beta human papillomaviruses

M Tommasino - Virus research, 2017 - Elsevier
The beta genus comprises more than 50 beta human papillomavirus (HPV) types that are
suspected to be involved, together with ultraviolet (UV) irradiation, in the development of non …

An emerging issue in oncogenic virology: the role of beta human papillomavirus types in the development of cutaneous squamous cell carcinoma

DE Rollison, D Viarisio, RP Amorrortu, T Gheit… - Journal of …, 2019 - Am Soc Microbiol
Evidence suggests that beta human papillomaviruses (HPVs), together with ultraviolet
radiation, contribute to the development of cutaneous squamous cell carcinoma. Beta HPVs …

Human papillomaviruses: shared and distinct pathways for pathogenesis

DA Galloway, LA Laimins - Current opinion in virology, 2015 - Elsevier
Highlights•HPVs infect epithelia cells and link their life cycles to differentiation.•HPVs are
grouped into five genera including alpha and beta viruses.•Alpha HPVs cause anogenital …

Cutaneous HPV8 and MmuPV1 E6 proteins target the NOTCH and TGF-β tumor suppressors to inhibit differentiation and sustain keratinocyte proliferation

JM Meyers, A Uberoi, M Grace, PF Lambert… - PLoS …, 2017 - journals.plos.org
Cutaneous beta-papillomaviruses are associated with non-melanoma skin cancers that
arise in patients who suffer from a rare genetic disorder, Epidermodysplasia verruciformis …

The role of the DNA damage response throughout the papillomavirus life cycle

CC McKinney, KL Hussmann, AA McBride - Viruses, 2015 - mdpi.com
The DNA damage response (DDR) maintains genomic integrity through an elaborate
network of signaling pathways that sense DNA damage and recruit effector factors to repair …

High-risk alphapapillomavirus oncogenes impair the homologous recombination pathway

NA Wallace, S Khanal, KL Robinson… - Journal of …, 2017 - Am Soc Microbiol
Persistent high-risk genus human Alphapapillomavirus (HPV) infections cause nearly every
cervical carcinoma and a subset of tumors in the oropharyngeal tract. During the decades …

Molecular mechanisms of MmuPV1 E6 and E7 and implications for human disease

JC Romero-Masters, PF Lambert, K Munger - Viruses, 2022 - mdpi.com
Human papillomaviruses (HPVs) cause a substantial amount of human disease from benign
disease such as warts to malignant cancers including cervical carcinoma, head and neck …

[HTML][HTML] The interplay of UV and cutaneous papillomavirus infection in skin cancer development

D Hasche, S Stephan, I Braspenning-Wesch… - PLoS …, 2017 - journals.plos.org
Cutaneous human papillomaviruses (HPVs) are considered as cofactors for non-melanoma
skin cancer (NMSC) development, especially in association with UVB. Extensively studied …

Breaking the DNA damage response to improve cervical cancer treatment

HW Wieringa, AGJ van der Zee, EGE de Vries… - Cancer treatment …, 2016 - Elsevier
Every year, cervical cancer affects∼ 500,000 women worldwide, and∼ 275,000 patients die
of this disease. The addition of platin-based chemotherapy to primary radiotherapy has …