Mitochondria and chloroplasts are major sources of free radical generation in living
organisms. Because of this, these organelles require strong protection from free radicals and …

Parkinson's disease (PD) is the second most common neurodegenerative disorder that is
characterized by two major neuropathological hallmarks: the degeneration of dopaminergic …

Studying the function of common genetic variants in primary human tissues and during
development is challenging. To address this, we use an efficient multiplexing strategy to …

Recent studies have shown that impairment of autophagy is related to the pathogenesis of
Parkinson's disease (PD), and small molecular autophagy enhancers are suggested to be …

Tumor hypoxia reduces the effectiveness of radiation therapy by limiting the biologically
effective dose. An acute increase in tumor oxygenation before radiation treatment should …

Organisms are constantly exposed to a broad range of pathological and stress-inducing
agents, allergens and environmental chemicals that can induce infections, toxicity or other …

Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to
correct the causative gene mutation and establish animal models in neurodegenerative …

Parkinson's disease is a common neurodegenerative disease in the elderly, and
mitochondrial defects underlie the pathogenesis of PD. Impairment of mitochondrial …

Sulforaphane, a naturally occurring compound found in cruciferous vegetables, has been
shown to be neuroprotective in several neurological disorders. In this study, we sought to …

Parkinson's disease (PD) is the second most common progressive age-related
neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT …