Simple Summary Despite breakthroughs in medicine, cancer remains one of the most feared
diseases. Traditionally, chemotherapies have been the treatment of choice. However …

DNA damage can alter nucleotide sequences and lead to expression of dysfunctional
proteins that impact normal cellular physiology. Sources of DNA damage can be …

With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with
major key parameters that control cancer treatment management, such as diagnosis …

The importance of early cancer diagnosis and improved cancer therapy has been clear for
years and has initiated worldwide research towards new possibilities in the care strategy of …

Abstract Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability
and the maintenance of redox homeostasis can cumulatively contribute to tumor progression …

This year, more than 1 million Americans and more than 10 million people worldwide are
expected to be diagnosed with cancer, a disease commonly believed to be preventable …

Neoplasms are microcosms of evolution. Within a neoplasm, a mosaic of mutant cells
compete for space and resources, evade predation by the immune system and can even …

Most human tumors are highly heterogenous. We have hypothesized that this heterogeneity
results from a mutator phenotype. Our premise is that normal mutation rates are insufficient …

Recent data on DNA sequencing of human tumours have established that cancer cells
contain thousands of mutations. These data support the concept that cancer cells express a …

We have proposed that an early step in tumor progression is the expression of a mutator
phenotype resulting from mutations in genes that normally function in the maintenance of …