Histamine has been one of the most studied substances in medicine, playing a major role in
diverse (patho) physiological processes. It elicits its multifaceted modulatory functions by …

Cross-sectional study design is a type of observational study design. In a cross-sectional
study, the investigator measures the outcome and the exposures in the study participants at …

Histamine is a well-known mediator of inflammation that is released from mast cells and
basophils. To date, many studies using histamine receptor antagonists have shown that …

Numerical data that are normally distributed can be analyzed with parametric tests, that is,
tests which are based on the parameters that define a normal distribution curve. If the …

Background Allergic skin diseases are common in horses worldwide. The most common
causes are insect bites and environmental allergens. Objectives To review the current …

Background Our knowledge of etiopathogenesis of atopic dermatitis (AD) is largely derived
from skin biopsies, which are associated with pain, scarring and infection. In contrast, tape …

Pruritus (or itch) is an unpleasant sensation leading to a desire to scratch. In the epidermis,
are selective C or Aδ epidermal nerve endings which are pruriceptors. At their other ends …

The transfer of sweat to the skin surface without leakage is important for the homeostatic
regulation of skin and is impaired in atopic dermatitis. Although the precise composition of …

Atopic Dermatitis (AD), the most common chronic inflammatory skin disease, is
characterized by an overactive immune response to a host of environmental allergens and …

The catalytic mechanism of histidine decarboxylase (HDC), a pyridoxal‐5′‐phosphate
(PLP)‐dependent enzyme, was studied by using a computational QM/MM approach …