Pulmonary arterial hypertension (PAH) is a progressive and fatal disease without a cure.
The exact pathogenic mechanisms of PAH are complex and poorly understood, yet a …

Our laboratory is focused on investigating the supportive role of P53 towards the
maintenance of lung homeostasis. Acute lung injury, acute respiratory distress syndrome …

Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+
influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung …

Concentric pulmonary vascular wall thickening due partially to increased pulmonary artery
(PA) smooth muscle cell (PASMC) proliferation contributes to elevating pulmonary vascular …

Objective Because mitochondrial dysfunction is a key factor in the progression of pulmonary
hypertension, this study tested the hypothesis that transplantation of exogenous viable …

Cellular senescence is the arrest of normal cell division and is commonly associated with
aging. The interest in the role of cellular senescence in lung diseases derives from the …

Downregulated expression of K+ channels and decreased K+ currents in pulmonary artery
smooth muscle cells (PASMC) have been implicated in the development of sustained …

Background and Purpose Recent studies reported therapeutic effects of monotherapy with
either tumour suppressor p53 (p53) agonist or hypoxia‐inducible factor 2α (HIF‐2α) …

Circulating levels of endothelial miR-150 are reduced in pulmonary arterial hypertension
(PAH) and act as an independent predictor of patient survival, but links between endothelial …

Down syndrome (DS) is the most prevalent chromosomal disorder associated with a higher
incidence of pulmonary arterial hypertension (PAH). The dysfunction of vascular endothelial …