mTOR signaling in pulmonary vascular disease: pathogenic role and therapeutic target
A Babicheva, A Makino, JXJ Yuan - International journal of molecular …, 2021 - mdpi.com
Pulmonary arterial hypertension (PAH) is a progressive and fatal disease without a cure.
The exact pathogenic mechanisms of PAH are complex and poorly understood, yet a …
The exact pathogenic mechanisms of PAH are complex and poorly understood, yet a …
P53 in the impaired lungs
MA Uddin, N Barabutis - DNA repair, 2020 - Elsevier
Our laboratory is focused on investigating the supportive role of P53 towards the
maintenance of lung homeostasis. Acute lung injury, acute respiratory distress syndrome …
maintenance of lung homeostasis. Acute lung injury, acute respiratory distress syndrome …
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension
Z Wang, J Chen, A Babicheva… - … of Physiology-Cell …, 2021 - journals.physiology.org
Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+
influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung …
influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung …
Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation
J Chen, M Rodriguez, J Miao, J Liao… - … of Physiology-Lung …, 2022 - journals.physiology.org
Concentric pulmonary vascular wall thickening due partially to increased pulmonary artery
(PA) smooth muscle cell (PASMC) proliferation contributes to elevating pulmonary vascular …
(PA) smooth muscle cell (PASMC) proliferation contributes to elevating pulmonary vascular …
[HTML][HTML] Transplantation of viable mitochondria improves right ventricular performance and pulmonary artery remodeling in rats with pulmonary arterial hypertension
CH Hsu, JN Roan, SY Fang, MH Chiu, TT Cheng… - The Journal of Thoracic …, 2022 - Elsevier
Objective Because mitochondrial dysfunction is a key factor in the progression of pulmonary
hypertension, this study tested the hypothesis that transplantation of exogenous viable …
hypertension, this study tested the hypothesis that transplantation of exogenous viable …
Senescence alterations in pulmonary hypertension
I Roger, J Milara, N Belhadj, J Cortijo - Cells, 2021 - mdpi.com
Cellular senescence is the arrest of normal cell division and is commonly associated with
aging. The interest in the role of cellular senescence in lung diseases derives from the …
aging. The interest in the role of cellular senescence in lung diseases derives from the …
MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension
Downregulated expression of K+ channels and decreased K+ currents in pulmonary artery
smooth muscle cells (PASMC) have been implicated in the development of sustained …
smooth muscle cells (PASMC) have been implicated in the development of sustained …
Established pulmonary hypertension in rats was reversed by a combination of a HIF‐2α antagonist and a p53 agonist
Q Zheng, W Lu, H Yan, X Duan, Y Chen… - British journal of …, 2022 - Wiley Online Library
Background and Purpose Recent studies reported therapeutic effects of monotherapy with
either tumour suppressor p53 (p53) agonist or hypoxia‐inducible factor 2α (HIF‐2α) …
either tumour suppressor p53 (p53) agonist or hypoxia‐inducible factor 2α (HIF‐2α) …
miR-150-PTPMT1-cardiolipin signaling in pulmonary arterial hypertension
G Russomanno, KB Jo, VB Abdul-Salam… - … Therapy-Nucleic Acids, 2021 - cell.com
Circulating levels of endothelial miR-150 are reduced in pulmonary arterial hypertension
(PAH) and act as an independent predictor of patient survival, but links between endothelial …
(PAH) and act as an independent predictor of patient survival, but links between endothelial …
Isogenic pairs of induced-pluripotent stem-derived endothelial cells identify DYRK1A/PPARG/EGR1 pathway is responsible for Down syndrome-associated …
H Suginobe, H Ishida, Y Ishii, K Ueda… - Human Molecular …, 2024 - academic.oup.com
Down syndrome (DS) is the most prevalent chromosomal disorder associated with a higher
incidence of pulmonary arterial hypertension (PAH). The dysfunction of vascular endothelial …
incidence of pulmonary arterial hypertension (PAH). The dysfunction of vascular endothelial …