This report presents an overview of how machine learning is rapidly advancing clinical
translational imaging in ways that will aid in the early detection, prediction, and treatment of …

Sevoflurane, a volatile anaesthetic agent well-tolerated for inhalation induction, provides a
useful opportunity to elucidate the processes whereby halogenated ethers disrupt …

Background Anaesthetic drugs act at sites within the brain that undergo profound changes
during typical ageing. We postulated that anaesthesia-induced brain dynamics observed in …

Objectives Ketamine is an N-methyl-d-aspartate (NMDA) receptor antagonist commonly
administered as a general anesthetic. However, neural circuit mechanisms to explain …

Background General anaesthetics generate spatially defined brain oscillations in the EEG
that relate fundamentally to neural-circuit architecture. Few studies detailing the neural …

Background Intraoperative isoelectric electroencephalography (EEG) has been associated
with hypotension and postoperative delirium in adults. This international prospective …

Background In adults, frontal electroencephalogram patterns observed during propofol-
induced unconsciousness consist of slow oscillations (0.1 to 1 Hz) and coherent alpha …

Understanding anesthetic mechanisms with the goal of producing anesthetic states with
limited systemic side effects is a major objective of neuroscience research in …

Long-term consequences of anesthetic exposure in humans are not well understood. It is
possible that alterations in brain function occur beyond the initial anesthetic administration …

Abstract Study Objectives Intra-operative electroencephalographic (EEG) monitoring
utilizing the spectrogram allows visualization of children's brain response during anesthesia …