The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

Breast cancer is the most common malignancy in women worldwide. Metastasis is the
leading cause of high mortality in most cancers. Although predicting the early stage of breast …

Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …

Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a
(partial) activation of the epithelial–mesenchymal transition (EMT) programme. A …

Cancer stemness, defined as the self-renewal and tumor-initiation potential of cancer stem
cells (CSCs), is a cancer biology property featuring activation of CSC signaling networks …

Epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET) are
genetic determinants of cellular plasticity. These programs operate in physiological …

The tumor micro-environment often contains stiff and irregular-bundled collagen fibers that
are used by tumor cells to disseminate. It is still unclear how and to what extent, extracellular …

Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement
on SRC function. However, a significant body of work has defined Src family kinases as key …

Hippo signaling was first identified in Drosophila as a key controller of organ size by
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …

Aims: Lipid peroxidation occurring in lung adenocarcinoma (LUAD) cells leads to
ferroptosis. Lysophosphatidylcholine acyl-transferase 3 (LPCAT3) plays a key role in …