Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
Therapeutic approaches for cardiac regeneration and repair
H Hashimoto, EN Olson, R Bassel-Duby - Nature Reviews Cardiology, 2018 - nature.com
Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …
[HTML][HTML] Inhibition of fatty acid oxidation enables heart regeneration in adult mice
X Li, F Wu, S Günther, M Looso, C Kuenne, T Zhang… - Nature, 2023 - nature.com
Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …
The extracellular matrix protein agrin promotes heart regeneration in mice
E Bassat, YE Mutlak, A Genzelinakh, IY Shadrin… - Nature, 2017 - nature.com
The adult mammalian heart is non-regenerative owing to the post-mitotic nature of
cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of …
cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of …
Hypoxia induces heart regeneration in adult mice
Y Nakada, DC Canseco, SW Thet, S Abdisalaam… - Nature, 2017 - nature.com
The adult mammalian heart is incapable of regeneration following cardiomyocyte loss,
which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become …
which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become …
Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression
S Ruijtenberg, S van den Heuvel - Cell cycle, 2016 - Taylor & Francis
Cell proliferation and differentiation show a remarkable inverse relationship. Precursor cells
continue division before acquiring a fully differentiated state, while terminal differentiation …
continue division before acquiring a fully differentiated state, while terminal differentiation …
The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response
The mammalian heart has a remarkable regenerative capacity for a short period of time after
birth, after which the majority of cardiomyocytes permanently exit cell cycle. We sought to …
birth, after which the majority of cardiomyocytes permanently exit cell cycle. We sought to …
Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration
Background: The adult mammalian heart has limited regenerative capacity, mostly
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …
Pathological ventricular remodeling: mechanisms: part 1 of 2
Despite declines in heart failure morbidity and mortality with current therapies,
rehospitalization rates remain distressingly high, substantially affecting individuals, society …
rehospitalization rates remain distressingly high, substantially affecting individuals, society …
Hippo pathway effector Yap promotes cardiac regeneration
The adult mammalian heart has limited potential for regeneration. Thus, after injury,
cardiomyocytes are permanently lost, and contractility is diminished. In contrast, the …
cardiomyocytes are permanently lost, and contractility is diminished. In contrast, the …