Monkeypox virus (MPXV), which causes disease in humans, has for many years been
restricted to the African continent, with only a handful of sporadic cases in other parts of the …

Inflammasomes are innate immune mechanisms that promote inflammation by activating the
protease caspase‐1. Active caspase‐1 induces pyroptosis, a necrotic form of regulated cell …

Acute kidney injury (AKI) is a worldwide problem, and there is no effective drug to eliminate
AKI. The death of renal cells is an important pathological basis of intrinsic AKI. At present …

Host pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns
(PAMPs), which are molecular signatures shared by different pathogens. Recognition of …

Viruses are ubiquitous intracellular genetic parasites that heavily rely on the infected cell to
complete their replication life cycle. This dependency on the host machinery forces viruses …

Apoptosis is a form of cellular suicide initiated either via extracellular (extrinsic apoptosis) or
intracellular (intrinsic apoptosis) cues. This form of programmed cell death plays a crucial …

Background: The reemergence of monkeypox virus (Mpox, formerly monkeypox) in 2022 in
non-endemic countries has raised significant concerns for global health due to its high …

Abstract Caspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially
garnered attention for its regulatory role in extrinsic apoptosis. With advancing research, a …

In standard uses of CRISPR/Cas9 technology, the cutting of genomes and their efficient
repair are considered to go hand-in-hand to achieve desired genetic changes. This includes …

Viruses are widely used as a platform for the production of therapeutics. Vaccines containing
live, dead and components of viruses, gene therapy vectors and oncolytic viruses are key …