Clinical trial results presented in 2019 suggest that antibody-based removal of cerebral
amyloid β (Aβ) plaques may possibly clear tau tangles and modestly slow cognitive decline …

Although dementia has been described in ancient texts over many centuries (eg,“Be kind to
your father, even if his mind fail him.”–Old Testament: Sirach 3: 12), our knowledge of its …

Background Alzheimer's disease is a progressive, irreversible, and fatal disease for which
accumulation of amyloid beta is thought to play a key role in pathogenesis. Aducanumab is …

Alzheimer's disease is the primary cause of dementia worldwide, with an increasing
morbidity burden that may outstrip diagnosis and management capacity as the population …

Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …

We built and validated a deep learning algorithm predicting the individual diagnosis of
Alzheimer's disease (AD) and mild cognitive impairment who will convert to AD (c-MCI) …

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …

Structural magnetic resonance imaging (sMRI) has been widely used for computer-aided
diagnosis of neurodegenerative disorders, eg, Alzheimer's disease (AD), due to its …

Brain extraction is a critical preprocessing step in the analysis of neuroimaging studies
conducted with magnetic resonance imaging (MRI) and influences the accuracy of …

Structural magnetic resonance imaging (sMRI) is widely used for the brain neurological
disease diagnosis, which could reflect the variations of brain. However, due to the local …