Why does obesity cause diabetes?

S Klein, A Gastaldelli, H Yki-Järvinen, PE Scherer - Cell metabolism, 2022 - cell.com
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

AGA clinical practice update on lifestyle modification using diet and exercise to achieve weight loss in the management of nonalcoholic fatty liver disease: expert …

ZM Younossi, KE Corey, JK Lim - Gastroenterology, 2021 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease, with
global public health impact affecting more than 25% of the global population. NAFLD is …

Current treatment of non‐alcoholic fatty liver disease

R Paternostro, M Trauner - Journal of internal medicine, 2022 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) comprises a wide spectrum of pathologies
ranging from non‐alcoholic fatty liver (NAFL), characterized by simple steatosis without …

Diet and exercise in the prevention and treatment of type 2 diabetes mellitus

F Magkos, MF Hjorth, A Astrup - Nature Reviews Endocrinology, 2020 - nature.com
Evidence from observational studies and randomized trials suggests that prediabetes and
type 2 diabetes mellitus (T2DM) can develop in genetically susceptible individuals in …

Dietary carbohydrates and fats in nonalcoholic fatty liver disease

H Yki-Järvinen, PK Luukkonen, L Hodson… - Nature reviews …, 2021 - nature.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

GI Smith, M Shankaran, M Yoshino… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND An increase in intrahepatic triglyceride (IHTG) is the hallmark feature of
nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo …

ESPEN guideline on clinical nutrition in liver disease

M Plauth, W Bernal, S Dasarathy, M Merli, LD Plank… - Clinical nutrition, 2019 - Elsevier
This update of evidence-based guidelines (GL) aims to translate current evidence and
expert opinion into recommendations for multidisciplinary teams responsible for the optimal …

The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases

N Chalasani, Z Younossi, JE Lavine, M Charlton… - Hepatology, 2018 - journals.lww.com
This guidance provides a data‐supported approach to the diagnostic, therapeutic, and
preventive aspects of nonalcoholic fatty liver disease (NAFLD) care. A “Guidance” document …

[HTML][HTML] Ketogenic diets and chronic disease: weighing the benefits against the risks

L Crosby, B Davis, S Joshi, M Jardine, J Paul… - Frontiers in …, 2021 - frontiersin.org
Very-low-carbohydrate ketogenic diets have been long been used to reduce seizure
frequency and more recently have been promoted for a variety of health conditions …

Treatment of NAFLD with diet, physical activity and exercise

M Romero-Gómez, S Zelber-Sagi, M Trenell - Journal of hepatology, 2017 - Elsevier
Lifestyle intervention can be effective when treating non-alcoholic fatty liver diseases
(NAFLD) patients. Weight loss decreases cardiovascular and diabetes risk and can also …