The applications of peptides and antibodies to multiple targets have emerged as powerful
tools in research, diagnostics, vaccine development, and therapeutics. Antibodies are …

This is an analysis from a chemical point of view of the 46 drugs (34 New Chemical Entities
and 12 Biologics) approved by the FDA during 2017. The drugs included in the 2017 …

This work is not a typical review that is trying to cover all coupling reagents in-depth. This is
a personal account—it is written in the first person—seeking to summarize the 25 years of …

The increasing demand for synthetic peptides in various research fields raises a challenge,
namely, the development of greener methods for their preparation. Here we report on an …

It looks that a new era of antimicrobial peptides (AMPs) started with the discovery of
teixobactin, which is a “head to side-chain” cyclodepsipeptide. It was isolated from a soil …

The synthesis of peptides for both research and API production is conveniently carried out
using the solid-phase strategy. However, the main drawback of this approach is the large …

In recent years, the work of various research groups has allowed the substitution of the
hazardous solvents most widely used in solid-phase peptide synthesis, namely DMF, NMP …

Peptides of importance to both academia and industry are mostly synthesized in the solid-
phase mode using a two-dimensional scheme. The so-called Fmoc/t Bu strategy, where the …

Peptides displaying antimicrobial properties are being regarded as useful tools to evade
and combat antimicrobial resistance, a major public health challenge. Here we have …

Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have
been demonstrated to be a plausible alternative to the current arsenal of drugs that has …