Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Metabolites are intermediate products of cellular metabolism catalysed by various enzymes.
Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal …

Over 50% of patients with heart failure have preserved ejection fraction (HFpEF), rather than
reduced ejection fraction (HFrEF). The prevalence of HFpEF continues to increase, while the …

Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty
acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source …

Succinate serves as an essential circulating metabolite within the tricarboxylic acid (TCA)
cycle and functions as a substrate for succinate dehydrogenase (SDH), thereby contributing …

Biallelic pathogenic variants in subunits of succinyl-CoA synthetase (SCS), a tricarboxylic
acid (TCA) cycle enzyme, are associated with mitochondrial encephalomyopathy in humans …

Mitochondria are cellular powerhouses that generate energy through the electron transport
chain (ETC). The mitochondrial genome (mtDNA) encodes essential ETC proteins in a …

Lysine succinylation is a post-translational modification which alters protein function in both
physiological and pathological processes. Mindful that it requires succinyl-CoA, a metabolite …

Although recent studies demonstrate active mitochondrial metabolism in cancers, the
precise mechanisms through which mitochondrial factors contribute to cancer metastasis …

Stroke is a leading cause of mortality and disability worldwide. Ischemic cell death triggered
by the compromised supply of blood oxygen and glucose is one of the major …